GBM Facts

Glioblastoma Multiforme (GBM)

is the most aggressive type of primary brain tumor. It develops in the astrocytes (glue-like supportive tissue of the brain). With an ample blood supply, the cells reproduce quickly.

Causes

The cause of GBM is unknown. It is more common in men and older adults but can occur in anyone.

Symptoms

Common symptoms include headaches, vomiting, drowsiness, visual changes, and seizures caused by the pressure and swelling in the brain.

Prognosis

With "standard treatment," median survival is 14.6 months, and two year survival is 30%. Patients whose MGMT gene is shut off have prolonged survival rates.

Treatment

Depending on location and grade of tumor, a combination of surgery, radiation and chemotherapy (standard treatment) is typically used to treat GBM. Because GBM tumors can be difficult to remove completely and often recur quickly, many people choose to enroll in clinical trials when they have exhausted standard treatment options.

The above information is adapted from the American Brain Tumor Association.  For more information, see Patient Resources.